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In Today's Issue
- The Healthy Back Institute's Back Pain Relief Journal
- More Positive Research On Caffeine And Alzheimer's
- WARNING: The truth about Moles, Warts and Skintags...
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More Positive Research On Caffeine And Alzheimer's
Dear Reader,
Finally, caffeine gets some good press. A team of French and German scientists have found that caffeine has a positive effect on tau deposits, a well known sign of Alzheimer's disease in the brain, publishing their work just recently in the journal Neurobiology of Aging. It appears that giving regular doses of caffeine to mice bred to have tau proteins in their brains held off memory decline when compared to control mice. Such findings may well pave the way for a new class of medications to
treat (or perhaps prevent) Alzheimer's disease.
The two universally recognized physical signs of Alzheimer's disease are deposits of tau protein (clogging the inside of brain cells) and plaques of amyloid protein (between brain cells). It's hard to see these things in a living brain, which is why mice are used as research subjects in this area.
Science knows that Alzheimer's causes terrible problems with the metabolism in the cells of the brain; they end up not working, losing
connections with each other and over time dying off. This gradual deterioration is what causes the memory failure, trouble doing daily tasks, changes in personality and other symptoms of Alzheimer's disease, a condition that's a fact of life for an estimated 5 million Americans, with numbers expected to rise dramatically in the coming decades, as the population ages.
For the most recent study, the team looked at the effect of persistent, regular intake of caffeine on mice who had been
bred to have tau deposits... similar to what might been seen in human subjects. The mice were given caffeine in their water, and a control group was not given the substance in their drinking water. Turns out the tau mice who were chronic caffeine drinkers didn't develop the spatial memory impairments that researchers saw in the control group of mice.
Continues below...
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More Positive Research On Caffeine And Alzheimer's Continued...
What's more, the chemistry of the tau proteins in the hippocampus (involved in rodent memory) was distinctly different in the mice drinking caffeine. Caffeine also appears to reduce other pro inflammatory and oxidative stress markers in the hippocampus of the brain. These findings add weight to the idea that caffeine intake is helpful in mice that develop the tau deposits like those in humans. Watch for future medications to come from these most intriguing findings.
Earlier work on Alzheimer's has shown regular, moderate caffeine intake prevents declining memory in older adults and cuts the risk of being diagnosed with Alzheimer's disease. Some researchers have gone one step further and shown how intake of caffeine slows memory decline in mice that have been bred to develop the Alzheimer's hallmark amyloid plaques. It wasn't until this latest study on tau deposits that mice bred for the other hallmark physical symptom of disease showed a positive
response to caffeine.
The risks of Alzheimer's increase with age, family history, some genetic factors, a history of head trauma, hypertension at midlife, being diabetic or obese or having high cholesterol. We also know that a healthy, balanced diet and other lifestyle changes may impact that risk. Drinking coffee, or another caffeinated drink, over a lifetime appears to be beneficial, particularly to older adults or in the period before disease symptoms appear - a simple prevention
strategy you might want to consider.
To your good health,
Kirsten Whittaker
Daily Health Bulletin Editor
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Sources:
Original article:
http://www.medicalnewstoday.com/articles/275181.php
Alzheimer's Association on Alzheimer's disease:
http://www.alz.org/alzheimers_disease_what_is_alzheimers.asp
More on coffee and Alzheimer's disease:
http://www.coffeeandhealth.org/research-centre/neurodegenerativedisorders/coffee-and-alzheimer's-disease/
Alzheimer's facts and figures 2014:
http://www.alz.org/alzheimers_disease_facts_and_figures.asp#quickFacts
Study abstract, September 2014, Neurobiology of Aging:
http://www.neurobiologyofaging.org/article/S0197-4580(14)00284-X/abstract
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